Author

Ashir Borah

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Open access Sep 2026

Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response.

The DNA damage response (DDR) is a sophisticated network of cellular pathways whose perturbation leads to genome instability and is a key hallmark of oncogenesis. Here, we present data from 32 genome-scale loss-of-function CRISPR interference chemical-genetic screens with inhibitors targeting core constituents of the D...

T. O'Loughlin, A. Arab, Sara Misiukiewicz et al. · Nature Chemical Biology · 0 citations

Open access Aug 2026

Aligning protein-generative models to experimental fitness with ProteinDPO

This work demonstrates how to provide task-specific information without losing the general knowledge learned during pretraining by using direct preference optimization to align a structure-conditioned protein language model to preferentially generate stable protein sequences.

Talal Widatalla, Ashir Borah, Samuel H. King et al. · Nature Methods · 3 citations