Ashleigh H. Wake

Ultra-high field functional magnetic resonance imaging reveals subregional hypothalamic and brainstem activation patterns in response to noxious heat stimuli in complex regional pain syndrome.

This study provides the first evidence of subregional hypothalamic activation in CRPS in response to noxious stimulation, and indicates altered autonomic circuits may contribute to ongoing pain in CRPS, identifying them as therapeutic targets for this debilitating chronic pain condition.