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Author

Ashley Harlock

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2 papers indexed here

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Open access Sep 2026

A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration

It is shown that APOE4 pericytes transition into myofibroblasts that secrete fibronectin, which promotes vascular amyloid accumulation in AD, and elevated TGF-β signaling is identified as the driver of this pericyte-to-myofibroblast transition.

B. Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo et al. · 0 citations
Open access Aug 2026

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains

An iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”) is developed and establishes a robust model for investigating protein inclusions in human iPSC-derived brain tissue.

Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al. · 2 citations

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