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Author

Ashley Hedrick

2 papers indexed here

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Sep 2026

Gene expression and brain pathology at the early stages of bilateral chronic cerebral hypoperfusion in the female mouse brain.

Chronic cerebral hypoperfusion (CCH) is a major risk factor for neurodegenerative diseases, including vascular dementia (VD). It is well documented that sex differences account for variability in progression and outcomes in cerebrovascular pathophysiology and dementia risk. Despite extensive study of VD, most mechanist...

Sarra Limam, A. Mazzarella, Randall Hernandez-Jimenez et al. · 0 citations
Open access Aug 2026

LncRNA Gas5, a Target of the Nonsense-Mediated Decay Pathway in the Brain, Regulates Neuroinflammation and Neurodegenerative Disease Pathways in a Tauopathy Mouse Model

Dysregulation of target genes of nonsense-mediated decay (NMD) in the brain remains sparsely known in tauopathies. PS19 transgenic mice expressing human mutant P301S tau were evaluated for levels of lncRNA Gas5, a target of NMD. The results show Gas5 decreased in the brains of PS19 mice as they aged. We evaluated the c...

Meredith Krause-Hauch, Bang-Mei Wang, Rekha S. Patel et al. · 0 citations

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