Most polygenic scores (PS) for type 1 diabetes were developed using European (EUR) ancestry datasets, limiting performance in non-European (non-EUR) populations. We evaluated novel type 1 diabetes PS across diverse populations to assess whether newer models improve prediction in underrepresented populations. Seven type...
Stella Nam, R. Kreienkamp, Jiang Li et al.· medRxiv· 0 citations
GenProb-PCSM transforms complex germline findings into a single inherited risk score for PCSM and metastatic progression and may facilitate clinical implementation of germline prognostic assessment in PCa.
Jun Wei, Zhu-Qing Shi, Lucy Lu et al.· The Prostate· 0 citations
BCa and inherited genetic susceptibility jointly contribute to increased risk of multiple common diseases, supporting the integration of genetic risk stratification into survivorship care.
Annabelle Ashworth, Zhu-Qing Shi, Huy Tran et al.· JNCI Cancer Spectrum· 0 citations
An integrated continuum genetic risk model, GenProb-PCa, improves PCa risk stratification beyond binary approaches by capturing heterogeneity in inherited risk and may enable more precise risk-based screening strategies.
Zhu-Qing Shi, A. Mulford, Jun Wei et al.· Journal of Medical Genetics· 0 citations
This study provides the most comprehensive assessment of IBS genetics to date, demonstrating reproducible polygenic inheritance and linking IBS risk to convergent neurogastrointestinal and novel cardiometabolic mechanisms, highlight specific biological pathways and actionable mechanisms and outline translational opport...
Biagio Di Lorenzo, L. Camargo Tavares, Cristian Díaz-Muñoz et al.· Gut· 0 citations
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