Open access
Sep 2026
Molecular and structural basis for replication initiation and strand separation by human mitochondrial DNA polymerase γ
Abstract Defects in human mitochondrial DNA (mtDNA) replication can lead to somatic mutations associated with a range of devastating mitochondrial diseases. However, the molecular mechanisms governing the earliest steps of mtDNA replication and their fidelity remain poorly understood. Here, we found that DNA polymerase...
Viktoriia Sokolova, Gina Buchel, S. Strock et al.
· Nucleic Acids Research · 0 citations