Ashraf A. Aly

Design, click synthesis, and biological evaluation of novel uracil-1,2,3-triazole hybrids as dual EGFR/CDK1 inhibitors: antiproliferative activity, mechanistic insights, and in silico studies

A novel series of uracil–1,2,3-triazole hybrids was designed, synthesized, and evaluated as dual EGFR/CDK1 inhibitors to target cancer cell proliferation and survival. Synthesis was initiated via the nucleophilic substitution of 2-chloro-N-(1,3-dimethyl-2,6-dioxo-pyrimidin-4-yl)acetamide (3) with sodium azide, yielding...