Ashwag S. Alanazi

Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis.

AIMS To synthesize and evaluate a series of thiosemicarbazone derivatives (2a-2g) incorporating thiophene-2-carboxylic acid as urease inhibitors. MATERIALS AND METHODS The compounds were synthesized and characterized using modern spectroscopic techniques. In vitro urease inhibition was determined followed by computat...