Asish K. Ghosh

Context-Dependent Roles of p53 in Cellular Senescence and Fibrosis.

Cellular senescence is an irreversible growth arrest state and a hallmark of organismal aging. While induction of cellular senescence in healthy organs is undesirable, senescence of specific cell types can be beneficial in certain pathological milieus. For instance, the senescence of activated myofibroblasts helps to l...