Astrid Bertsche

Loose–patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1

Introduction The non-inactivating potassium channels Kv7.2 and Kv7.3 contribute to the neuronal resting membrane potential and regulate neuronal excitability. Previous studies have indicated a transcriptional downregulation of these channels in temporal lobe epilepsy, both in patients and in the pilocarpine-induced ani...