Author

Astrid Deschênes

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Sep 2026

Abstract B068: FYN and other Src family kinases antagonize response to RAS inhibition in pancreatic ductal adenocarcinoma

Oncogenic KRAS drives pancreatic ductal adenocarcinoma (PDAC), yet resistance to RAS antagonists limit benefits. To define therapeutic response and resistance mechanisms, we deployed two complementary preclinical PDAC models, including a degron-regulated KRASG12D-dependent transplantation model, and a Kras G12V-drive...

Hsiu-Chi Ting, Sun Kim, V. Gaeth et al. · Cancer Research · 0 citations

Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 3 citations