Atlanta G. Cook

DICER1-related tumour predisposition mutations increase 3p-miRNA function and HERVH activity

The DICER1 gene is mutated in cancer, including in DICER1-related tumour predisposition. Cancer-associated hotspot mutations have been reported in both catalytic domains of DICER and are predicted to disrupt miRNA biogenesis. To understand how these hotspot mutations contribute to cancer development, we generate cell l...