Aude Pascal

Spatial relief of Kinesin-1 auto-inhibition by Ensconsin regulates ncMTOCs localization and shapes microtubule networks.

During Drosophila oogenesis, the organization of microtubules (MTs) drives polarized transport and cytoplasmic flows. Although Kinesin-1 plays a central role in these processes, its molecular and spatial regulation remains poorly understood. Here, we show that Ensconsin, an activator of the Kinesin heavy chain (Khc), i...