Audrey A. Burnim

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Nucleases are crucial for various bacterial processes, including genome maintenance and host defense. Deoxydinucleases (diDNases), a class of Gram-positive bacteria–specific nucleases associated with mobile genetic elements, are homologous to nanoRNase C (NrnC) in Gram-negative bacteria but exhibit notable differences:...