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Audrey Street

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Open access Sep 2026

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

Using isogenic human induced pluripotent stem cell-derived microglia carrying the pathogenic MAPT IVS10+16 mutation, tau is identified as a regulator of microglial lysosomal function and degradative capacity is identified as a modifiable component of the microglial response to tau pathology.

Kylie J. Schache, Rui Zhang, Audrey Street et al. · 0 citations

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