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Author

Augustus J. Lowry

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Review Sep 2026

Lipid flip-flop in biological membranes: through the lens of TMEM16F.

The asymmetric distribution of phospholipids between membrane leaflets is a hallmark of all known cells, yet many fundamental questions about membrane lipid asymmetry remain unanswered. Why do cells invest energy to establish and maintain this thermodynamically unstable state? How do cells exploit lipid asymmetry to su...

Shan Z. Ke, Augustus J. Lowry, Maria A. Gonzalez Torres et al. · 0 citations
Open access Aug 2026

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function

A stratified molecular model of TMEM63B channelopathies in which the pathogenic variants progressively destabilize the hydrophobic gate, permitting lipid permeation at the resting state followed by force-induced ion and lipid co-transport through I475del is supported.

Augustus J. Lowry, P. Liang, Maria A. Gonzalez Torres et al. · 0 citations

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