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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Aundrietta Duncan

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Jul 2026

Abstract B069: Pharmacodynamic evidence of Wnt/β-catenin inhibition by tegavivint, a TBL1-directed transcriptional modulator, in advanced hepatocellular carcinoma: a phase 1 study

An integrated analysis of preclinical and clinical pharmacodynamic data characterizing tegavivint activity establishes TBL1 as a clinically actionable regulator of oncogenic transcription and demonstrates that tegavivint achieves pharmacodynamic modulation of the Wnt pathway through a differentiated downstream mechanis...

Aundrietta Duncan, Elena Ramirez, Julissa Simmons et al. · 0 citations

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