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Author

Aurélien Lathuilière

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Open access Oct 2026

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were...

Fausto Roveta, Augusto J. Mendes, V. Garibotto et al. · 0 citations
Open access Aug 2026

Optimal amyloid and tau CSF biomarkers for the detection of amyloid and tau PET positivity in a memory clinic population

Ratios combining biomarkers of both amyloid and tau, such as Aβ42/pTau, consistently outperformed individual biomarkers in detecting amyloid and tau PET positivity and enhanced clinical utility by highlighting ambiguous cases requiring further assessment.

Sophie Mutel, F. Ribaldi, Augusto J. Mendes et al. · 0 citations

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