Aurélien M. Badina

Carbonyl stress primes the metastable aging brain for Alzheimer’s disease

Alzheimer’s disease (AD) is defined by amyloid-β (Aβ) plaques and tau tangles, yet the inflammation that comes with it is only partly localized where those lesions accumulate. Using spatial transcriptomics on 16 human hippocampal sections containing adjacent cortex, we found that plaques concentrated in grey matter, es...