Avanthi Raghav

Cerebellar Syndrome as the Dominant Manifestation of Severe Chronic Phenytoin Toxicity

Background: Phenytoin continues to be widely prescribed for seizure disorders despite its narrow therapeutic index and saturable hepatic metabolism, resulting in dose-dependent non-linear pharmacokinetics. Consequently, relatively small increases in dose may lead to disproportionate elevations in serum phenytoin concen...