Clinical pharmacology encompasses a broad set of quantitative and translational tools: pharmacokinetics, pharmacodynamics, biomarkers, pharmacogenomics, modeling and simulation, and clinical and real-world evidence. Yet, the discipline’s true value lies not in the methods themselves. Its value lies in turning measureme...
M. Elmeliegy, Avery McIntosh· Clinical pharmacology and th...· 0 citations
Quantitative dose optimization in early phase clinical trials for investigational new drugs has been expanding across drug modalities and disease indications in response to the limitations of non‐quantitative or algorithmic methods of dose progression. In the context of the FDA's Project Optimus Initiative, which empha...
Kevin Roberts, Jeffrey Palmer, Jessica Volpe et al.· Pharmaceutical statistics· 0 citations
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