INDOLE-3-PROPIONIC ACID-MEDIATED NEPHROPROTECTION AGAINST GENTAMICIN INDUCED OXIDATIVE STRESS AND FERROPTOSIS IN HK-2 RENAL CELLS: AN IN VITRO STUDY
Objective: Gentamicin remains an effective aminoglycoside antibiotic; however, nephrotoxicity limits its therapeutic use. Proximal tubular epithelial injury induced by gentamicin involves oxidative stress, mitochondrial dysfunction, lipid peroxidation and ferroptosis. Indole-3-propionic acid (IPA), a gut microbiota-der...