Awaji Y. Safhi

Oncoviruses at the Crossroads of Ageing and Cancer: Molecular Mechanisms and Key Signalling Pathways.

Oncoviruses are responsible for a substantial fraction of human cancers and have emerged as critical modulators of host cellular pathways that also govern ageing. The convergence of viral oncogenesis, ageing, and cancer reflects shared molecular mechanisms, including genomic instability, epigenetic alterations, telomer...

Hydroxyurea-Loaded Nanostructured Lipid Carriers for Enhanced In Vitro Cytotoxicity and Drug Delivery.

Hydroxyurea (HU) is an established anticancer drug used to treat chronic myelogenous leukemia, but its therapeutic efficacy is limited by rapid clearance, variable bioavailability, and dose-related toxicity. This study aimed to improve HU delivery by developing hydroxyurea-loaded nanostructured lipid carriers (NLCs) us...

Integrated Transcriptomic, Network Pharmacology, and Machine-Learning Framework Identifies Candidate Phytochemical-Associated Targets in Lung Adenocarcinoma

A novel optimization of API release using hybrid models

Polysaccharide-based drug delivery systems have to be closely watched in terms of drug release in the body over time if they want to be able to achieve maximum therapeutic effectiveness and maintain controlled bioavailability. The work presents a data-driven framework that employs Raman spectroscopy and uncertainty...