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Author

Axel Abelein

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Open access Oct 2026

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer’s disease

Neurotoxic intermediates formed during amyloid-β(Aβ) aggregation are thought to drive Alzheimer’s disease, yet their rarity and transient nature have obscured their identity and formation pathways in the human brain. Here, we combine super-resolution microscopy and single-molecule functional imaging with kinetic modell...

Agnieszka Urbanek, A. Dear, David P. Rhodes et al. · 0 citations
Open access Jul 2026

Single-molecule mass measurements uncover shifting RNA interactions during condensate phase transitions

It is demonstrated that single-molecule mass measurements with mass photometry can capture RNA-protein interactions in phase-separated protein systems and can distinguish between charge neutralization, which drives coacervation, and complex formation, which mediates phase re-entry, making it a highly complementary tool...

Axel Leppert, Jesper Shiapan, Irena Papageorgiou et al. · 0 citations

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