Clinical performance evaluation of a high-throughput real-time PCR platform for congenital cytomegalovirus screening on saliva swabs with quantitative reporting thresholds.
BACKGROUND Congenital cytomegalovirus (cCMV) is typically diagnosed using nucleic acid amplification testing on saliva followed by urine confirmation if positive. Major challenges in saliva screening include low positive predictive value (PPV) and throughput constraints. We validated the cobas CMV assay on the cobas 88...