Human Monocytic Models Reveal Genotype-Dependent Inflammatory Programs in VEXAS Syndrome.
OBJECTIVES VEXAS syndrome is a severe X-linked autoinflammatory disorder caused by somatic mutations in ubiquitin-like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype-specific inflammatory programs and identify potential therapeutic targets. METHO...