Ayane de Sá Resende

Pde1b controls cyclic nucleotide signaling in cDC1 and macrophages to regulate immune responses.

Cyclic nucleotides cAMP and cGMP are potent suppressors of immune activation, yet how their intracellular levels are regulated within antigen-presenting myeloid cells remains undefined. Here we identify phosphodiesterase 1B (Pde1b) as a lineage-restricted regulator of cyclic nucleotide signaling in conventional type 1...