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Ayca Aktas-Sukuroglu

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Open access Aug 2026

Difluoromethoxy-Substituted Hexahydroquinolines as Multi-Target Anti-Inflammatory Agents: Mechanistic and Metabolomic Insights

Abstract In this study, a series of 15 difluoromethoxy-substituted hexahydroquinoline (HHQ) derivatives were synthesized and evaluated for their anti-inflammatory potential. The cytotoxicity profiles of the synthesized compounds were assessed using the MTT assay in LPS-stimulated RAW 264.7 macrophages. At 10 μM, severa...

Ezgi Pehlivanlar-Yavrucu, Ayca Aktas-Sukuroglu, Meryem Temiz-Resitoglu et al. · 0 citations

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