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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ayelet Fishman

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Open access Jul 2026

Behind substrate specificity switch in lactate dehydrogenase: Active-site loop dynamics and epistatic enhancement.

Substrate specificity in lactate dehydrogenases (LDHs) controls metabolic flux and remains a central challenge in enzyme engineering, particularly when closely related substrates differ by only a single carboxylate group. Although Q102 (equivalent to Gln86 in Geobacillus stearothermophilus L-LDH) is recognized as a can...

Hanfeng Cai, S. Shulami, T. Hrenar et al. · 0 citations

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