Review
Sep 2026
The evolving landscape of drug targets.
L. Halip, Sorin Avram, John P. Overington et al.
· Nature reviews. Drug discove... · 0 citations
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Aug 2026
Sulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery
Covalent probes and therapeutics must balance electrophilicity and stability for function in biological systems, yet gains in stability can sacrifice proteome coverage and limit ligand discovery. Here, we show that single-atom N-to-C substitutions of sulfonyl purines at the nucleofuge position decouple reactivity fro...
Zhihong Li, Madeleine L. Ware, Phillip W. Gingrich et al.
· Journal of the American Chem... · 0 citations