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Review Open access Aug 2026

Dasatinib as a Network-modulating Tyrosine Kinase Inhibitor in Philadelphia Chromosome-positive Leukemias: Integration of BCR-ABL1, SRC, and MAPK Signaling

Philadelphia chromosome-positive leukemias involve signaling systems beyond BCR-ABL1, and treatment response may depend on this wider network biology. Second-generation BCR-ABL1 tyrosine kinase inhibitors such as dasatinib, nilotinib, and bosutinib show variable clinical responses according to diagnosis and disease sta...

S. Vanitha, R. Kothai, B. Arul · 0 citations

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