867. The COMB-study on varenicline and bupropion for alcohol use disorder: effects of/on WHO drinking risk levels, sex, self-reported heredity and nicotine use
Abstract Background Alcohol Use Disorder (AUD) afflicts 100 million people, causes 3 million deaths/year and generates enormous costs. Available treatments have limited effects. The dopamine deficiency hypothesis of AUD posits that ethanol intake is driven by negative reinforcement generated by a low dopamine state in...