Open access
Aug 2026
CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice
Summary The transcription factor ATOH1 is a master regulator of mechanosensory hair-cell (HC) development in the ear. Here, we report that its target gene Casz1 regulates the maturation of outer HCs (OHCs). Genetic deletion of Casz1 during (but not after) cochlear development in the mouse caused: hearing loss; disorgan...
Y. Nakano, E. C. Driver, Ning Hu et al.
· iScience · 0 citations