Theoretical Considerations Regarding the Role of Hyperinsulinemia and Insulin/IGF Signaling in Cancer Metabolic Reprogramming: Potential Mechanisms and Therapeutic Vulnerabilities
Hyperinsulinemia is increasingly recognized as a systemic factor that can promote tumor progression by amplifying insulin receptor and insulin-like growth factor (IGF) signaling, reshaping cancer-cell metabolism, and influencing the tumor microenvironment. Commonly associated with obesity, type 2 diabetes, and metaboli...