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Review Open access Oct 2026

Theoretical Considerations Regarding the Role of Hyperinsulinemia and Insulin/IGF Signaling in Cancer Metabolic Reprogramming: Potential Mechanisms and Therapeutic Vulnerabilities

Hyperinsulinemia is increasingly recognized as a systemic factor that can promote tumor progression by amplifying insulin receptor and insulin-like growth factor (IGF) signaling, reshaping cancer-cell metabolism, and influencing the tumor microenvironment. Commonly associated with obesity, type 2 diabetes, and metaboli...

B. Chae · 0 citations

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