Author

B. Chain

3 papers indexed here

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Open access Oct 2026

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

It is shown that the neoplastic evolution of mismatch repair deficient (MMRd) clones leads to large-scale and sustained reorganisation of the T-cell repertoire in colon and peripheral blood, which defines the local and circulating TCR landscape associated with colonic neoplasia in Lynch syndrome and provides a framewor...

Penelope V. Edwards, O. Swinyard, T. Ronel et al. · bioRxiv · 0 citations

Open access Aug 2026

The Thymic Microenvironment Shapes Age‐Related Qualitative Changes in the TCR Repertoire

The experiments show that the old thymus generates qualitatively different TCR repertoires than young thymus and the non‐lymphoid compartment of the thymus contributes strongly to these changes and to age‐associated decline in TCR repertoire diversity.

Jasmine Rowell, Diana C. Yánez, Susan Ross et al. · Aging Cell · 0 citations

Open access Aug 2026

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.

N. Kehl, T. Wagner, Simon Steiger et al. · Cancer Cell · 1 citation