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Open access Oct 2026

Efficacy and safety of litifilimab in cutaneous lupus erythematosus: 24-week results of the randomized phase 2 study, AMETHYST.

BACKGROUND Cutaneous lupus erythematosus (CLE) is a serious autoimmune disease with no approved targeted treatments. OBJECTIVE Evaluate the efficacy and safety of litifilimab in AMETHYST Part A (Phase 2). METHODS AMETHYST is a randomized, double-blind, placebo-controlled, Phase 2/3 study that investigates litifilim...

J. Merola, Victoria P. Werth, B. Chong et al. · 0 citations
Open access Aug 2026

Skin-Specific Outcomes of Brepocitinib in Patients With Dermatomyositis: Secondary Analysis of a Phase 3 Randomized Clinical Trial.

Importance Brepocitinib, a first-in-class oral, selective TYK2 and JAK1 inhibitor, demonstrated broad efficacy in a phase 3 randomized clinical trial in dermatomyositis. Objective To evaluate the effects of brepocitinib on cutaneous disease activity, itch, skin-related quality of life (QOL), and achievement of remiss...

Aaron R. Mangold, A. Haemel, Neda Shahriari et al. · 1 citation

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