Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
OutLAST Regulators are designed proteins that reprogram critical T cell signaling pathways to enhance functional persistence and are implemented as compact genetic modules compatible with standard viral vectors and cell therapy manufacturing processes, creating a powerful platform for programming new functions into enh...
S. Boyken, Sean A. Merillat, Robert A. Langan et al.· bioRxiv· 0 citations
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