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Author

B. Drapkin

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Jul 2026

Abstract PR006: Target discovery in rare cancers enabled by transcriptome-based virtual CRISPR screening

It is demonstrated that machine learning applied to transcriptomic data can uncover novel cancer vulnerabilities and actionable targets in individual tumors, even in the absence of functional screening, which may represent a scalable approach to advance precision oncology in rare and/or under-characterized cancer types...

Ananthan Sadagopan, Bingchen Li, Jiao Li et al. · 0 citations
Open access Jul 2026

PAX5 modulates vascularization and contributes to neuroendocrine lineage transition during carcinoma progression.

It is found that PAX5, a neural/lymphatic transcription factor, contributed to neuroendocrine (NE) lineage transition, and targeting PAX5 and its downstream signaling may modulate lineage transitions responsible for treatment failure in both SCNCs and adenocarcinomas.

Ailing Wu, Yujie Hao, Xuemiao Yan et al. · 0 citations

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