Open access
Aug 2026
Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer
N-Nitrosodimethylamine (NDMA) is present in food, water, and drugs and is considered a probable human carcinogen by the International Agency for Research on Cancer. The mechanism of action of NDMA involves the generation of carcinogenic methyl lesions such as 3-methyladenine (3MeA) on DNA bases. Alkyladenine DNA Glycos...
Jennifer E. Kay, J. Corrigan, Lindsay B. Volk et al.
· DNA Repair · 0 citations