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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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B. Glaunsinger

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Open access Sep 2026

Mutational screening reveals a cluster of residues within the SARS-CoV-2 nsp1 N-terminus that confers RNA-targeting selectivity

The SARS-CoV-2 nsp1 protein is a virulence factor that broadly inhibits cellular gene expression. Although cellular mRNAs are translationally inhibited by nsp1 and subsequently degraded, viral transcripts possess a 5′ leader sequence (CoV2L) that enables them to escape nsp1-mediated repression. Both transcript targetin...

Jaresley V. Guillen, Sherzod A. Tokamov, B. Glaunsinger · 0 citations

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