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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

B. Karikalan

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2 papers indexed here

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Review Sep 2026

Targeting TP53 in triple-negative breast cancer: Molecular pathogenesis, therapeutic implications, and emerging pharmacological strategies.

Triple-negative breast cancer (TNBC) remains a highly aggressive and therapeutically challenging subtype, defined by the absence of oestrogen, progesterone, and HER2 expression. Tumour Protein 53 (TP53) mutations represent the most frequent genetic alteration, occurring in over 80% of cases and driving tumour initiatio...

B. Karikalan, Ye Htut Linn, Shiueh-Lian Mok · 0 citations
Open access Aug 2026

Targeting Apoptosis and Autophagy in Cancer: Molecular Mechanisms, Therapeutic Modulators, Clinical Advances, and Future Perspectives

Cancer is a leading cause of mortality globally. Apoptosis, a highly selective and natural mechanism of programmed cell death, and autophagy, a physiological state at the cellular level that eliminates misfolded proteins and aberrant organelles, are both related. Apoptotic cell death occurs through caspase activation,...

S. Chakravarthi, B. Karikalan, Prarthana Kalerammana Gopalakrishna et al. · 0 citations

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