Author

B. Kobilka

2 papers indexed here

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Sep 2026

Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.

Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration-approved therapy directly targets fibrotic remodeling in the heart. To address this unmet clinical need, we used a multidimensional drug discovery pipeline centered on a human induced pluripotent stem cel...

Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al. · Science · 0 citations

Open access Aug 2026

A biased allosteric modulator is a molecular glue for β2AR dimerization.

Family A G-protein-coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests that they can form dimers with distinct signalling properties1-3. However, the mechanisms and therapeutic potential of such dimerization remain poorly understood. Here we show that AP-7-168, an optimized deri...

Jiemin Shen, T. Peddada, Konstantin E. Komolov et al. · Nature · 2 citations