Mechanosensitive HEG1-NOTCH1 signals governs endothelial cell function in the pathogenesis of pulmonary hypertension
Endothelial cells (ECs) adapted mechanosensitivity to flow shear-stress are critical for vascular homeostasis. HEG1 as an endothelial mechanosensitive gene exerts anti-hypertensive and atheroprotective effects, yet its regulation of pulmonary endothelial function for pulmonary hypertension (PH) pathogenesis and t...