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Sep 2026

Low Uptake of [18F]Flutemetamol in the Mouse Brain Prevents Non-invasive Quantification of Myelin

Direct in vivo imaging of myelin would greatly benefit research on demyelinating diseases such as multiple sclerosis but remains technically challenging. This study evaluated whether the amyloid-β radiotracer [18F]Flutemetamol is suitable for PET/CT imaging of myelin in the murine cuprizone model of demyelination. Ma...

Anna Schildt, Malena Beecken, T. Lindner et al. · 0 citations
Open access Sep 2026

No evidence of major integrative brain clearance impairment in an Alzheimer´s disease model of transgenic APPswe/PS1dE9 mice

The findings indicate that the APPswe/PS1dE9 mouse model does not exhibit evidence of major integrative brain clearance impairment, despite this being a hallmark of sporadic AD in humans and suggest limitations of this model for studying clearance-related mechanisms of late-onset AD should be acknowledged when planning...

L. Müller, Charlotte Köhler, T. Lindner et al. · 0 citations

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