Metastasizing cancer cells require metabolic plasticity to adapt to the microenvironment of the target organ. Analyzing metabolites in interstitial fluids, we found that the liver microenvironment is devoid of cystine but contains high concentrations of glutathione (GSH). Detailed mechanistic analysis revealed that can...
Felix C. E. Vogel, F. Röhrig, Danny Schilling et al.· bioRxiv· 0 citations
Understanding the mechanisms of metastasis is one of the most pressing issues in cancer therapy. Metastasis-associated in colon cancer 1 (MACC1) is an important biomarker and functional driver of tumor progression and metastasis. However, the molecular mechanisms underlying its activity remain incompletely understood....
Fabian Zincke, D. Kobelt, Susan Kläger et al.· Biomolecules· 0 citations
This work serendipitously identified CEM198 as the first high-affinity ligand of tubulin-tyrosine ligase (TTL), introducing CEM198 as a chemical probe for investigating the tubulin tyrosination–detyrosination and demonstrating the potential of chemoproteomics to uncover novel modulators of microtubule dynamics.
Rubaba R. Abanti, Eleftheria A. Georgiou, D. Makarov et al.· bioRxiv· 0 citations
This study shows that signalling by the multifunctional receptor kinase SUB in cell wall integrity involves two functionally distinct cell surface complexes whose activities are attenuated by sequential endocytosis, revealing a stress–growth trade-off.
Rodion Boikine, Ajeet Chaudhary, J. Mergner et al.· Nature Plants· 1 citation
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