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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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B. M. Bolker

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Open access Aug 2026

Design-informed Size Factor Estimation

Accurate normalization is essential for differential expression analysis of RNA-sequencing data. Popular normalization methods such as the median-of-ratios and trimmed mean of M-values do not leverage information from the experimental design. This may be inefficient in experiments with large-scale systematic expression...

Todd Pocuca, Guillaume Paré, B. M. Bolker · 0 citations

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