Cyclosporine-A Nanotherapeutics Ameliorate Lupus Nephritis by Reprogramming the Gut-Microbial Metabolic Axis and Systemic Inflammation.
Systemic lupus erythematosus (SLE) is a debilitating autoimmune disease fueled by abnormal immune responses and metabolic dysregulation, often leading to life-threatening lupus nephritis (LN). While Cyclosporine A (CsA) is a potent therapeutic agent, its clinical utility is severely constrained by systemic off-target t...