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Author

B. Oyinloye

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Open access Sep 2026

Acetone Extract of Annona Muricata Linn Leaf Counteracts Hyperglycemia-Associated Metabolic Dysregulation by Modulating Oxidative Stress and Hepatic Carbohydrate Metabolism in Streptozotocin-Induced Diabetic Rats.

Annona muricata is widely recognized for its rich phenolic composition and potent antioxidant activity, suggesting therapeutic potential in diabetes management. This study investigated the mechanistic antidiabetic effects of acetone extract of A. muricata leaf on hepatic carbohydrate metabolism, oxidative stress, and h...

Benjamin Olusola Omiyale, B. E. Ekundayo, Olutosin Samuel Olusola et al. · 0 citations
Aug 2026

Activity cliffs resist prediction within and across protein kinases: a leakage-controlled machine-learning analysis of structure-potency discontinuities.

Activity cliffs, that is pairs of closely related molecules with large potency differences, limit the reliability of structure-activity models, and it is commonly assumed that the chemistry responsible for a cliff carries information that generalizes to other targets. We tested this assumption directly across the prote...

Samuel S. Agboola, O. Agboola, O. Olasehinde et al. · 0 citations

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