Abstract Motivation Although large scale genome-wide association studies (GWAS) have identified many risk variants for psychiatric traits their functional implication remain largely unknown. One potential mechanism for their risk is through cellular context-dependent epigenetics such as methylation. Previous methodolog...
Admixed individuals have been understudied in medical research largely due to their complex genetic ancestries. However, the consideration of admixture can identify ancestry-enriched genetic associations, delineating genetic underpinnings of cross-population phenotypic variation. Here, we performed admixture mapping in...
R. Mandla, Zhuo-Zheng Shi, Kangcheng Hou et al.· Nature Communications· 0 citations
Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...
L. Hu, T. Tan, K. Yuan et al.· medRxiv· 0 citations
Leveraging multiancestry and multi-biobank data from the All of Us Research Program and the UK Biobank improves polygenic prediction models for complex traits and diseases, especially for under-represented populations.
K. Tsuo, Zhuo-Zheng Shi, Tian Ge et al.· Nature Genetics· 0 citations
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