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Author

B. Podesser

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Open access Oct 2026

Empagliflozin promotes reverse remodeling via cardiometabolic reprogramming in established pressure-overload left ventricular hypertrophy

Left ventricular hypertrophy (LVH) due to chronic pressure overload is a major precursor of heart failure (HF) and is characterized by metabolic inflexibility and mitochondrial dysfunction. Sodium–glucose cotransporter-2 inhibitors (SGLT2i) improve HF outcomes; however, their myocardial mechanisms in LVH remain i...

M. Ernst, A. A. Goncalves, C. Dostal et al. · 0 citations
Open access Oct 2026

Comprehensive cardiac, vascular, and pulmonary characterization of a cardiometabolic HFpEF model.

BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome in which translational progress is limited by experimental models that insufficiently reflect the cardiometabolic phenotype while affecting endogenous endothelial function. We aimed to characterize a cardiometabolic "two-hit"...

I. Aykac, Christoph A. Baumgartner, O. Hamza et al. · 0 citations

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